Notorious for its dark humour, the show follows narcissistic sociopath Jill Tyrell (Julia Davis) – who manages a beauty parlour alongside her moronic, asthmatic assistant Linda (Ruth Jones) – as she learns that her husband (Kevin Eldon) has cancer. She uses this fact to manipulate new neighbour Cathy Cole (Rebecca Front), a wheelchair user with multiple sclerosis with whose husband Don (Angus Deayton), a womanising doctor, Jill has become obsessed.